Loop quantum gravity, as one branch of quantum gravity, holds the potential to explore the fundamental nature of black holes. Recently, according to the quantum Oppenheimer-Snyder model in loop quantum cosmology, a novel loop quantum corrected black hole in de Sitter spacetime has been discovered. Here, we first investigate the corresponding quasinormal modes and late-time behavior of massless neutral scalar field perturbations based on such a quantum-modified black hole in de Sitter spacetime. The frequency and time domain analysis of the lowest-lying quasinormal modes is derived by the Prony method, the matrix method as well as Wentzel-Kramers-Brillouin approximation. The influences of loop quantum correction, the black hole mass ratio, and the cosmological constant on the quasinormal frequencies are studied in detail. The late-time behaviors of quantum-modified black holes possess an exponential decay, which is mainly determined not only by the multipole number but also by the cosmological constant. The impact of loop quantum correction on the late-time tail is negligible, but it has a significant impact on damping oscillation. To explore spacetime singularities, we examine the validity of strong cosmic censorship for a near-extremal quantum-modified black hole in de Sitter spacetime. As a result, it is found that the strong cosmic censorship is destroyed as the black hole approaches the near-extremal limit, but the violation becomes weaker as the cosmological constant and the loop quantum correction increase.